Endocrine Abstracts

Background: Immune checkpoint Inhibitors (ICIs) have revolutionized the treatment of vast array of cancers. Despite their efficacy, ICIs can cause various side effects related to the mechanism of action. Immune-related endocrine events (irEEs) are one of the most common immune-related adverse events (irAEs), accounting for 8.1% of all cases. We report two patients with durable responses to ICIs and concurrent serious irEEs.Case 1: A 58-year-old woman wit...

Adolescence is one of the most dynamic periods of development, which is highly sensitive to changes induced by stressors. Disruption in hormonal balance associated with stress have a negative impact on puberty and reproductive function. The aim of the work was to study the long-term endocrine effects of chronic pubertal stress in rats. On the 22 postnatal day (PND), the Wistar rats were separated from their mothers and sorted by sex into individual cages, so that animals from ...

Background: The registry is the main source of information about patients with acromegaly for assessing the quality of medical care, effectiveness of treatment, determining the compliance of real clinical practice with existing standards and patient management protocols.Aims: To analyze the epidemiological, demographic and clinical characteristics of acromegaly in the Russian Federation and the effectiveness of various treatment methods.<p class="abs...

According to previous research microRNA (miR) are expressed differently in corticotropinoma and ACTH-secreting neuroendocrine tumors. MiR are released into circulation by several mechanisms and considered to be promising biomarkers.Objective: To evaluate whether preselected miR are differently expressed in plasma samples of patients with ACTH-dependent Cushing’s syndrome (CS).Materials and methods: The blood samples were colle...

Introduction: A growth hormone-secreting pituitary adenoma (GH-PA) increases the risk of complications and death. It’s management is determined by MRI data and decrease of insulin-like growth factor-1 (IGF-1) during the octreotide suppression test (OST). Currently, there is evidence that MRI-T2-hypointensive somatotropinoma and high expression of somatostatin receptors type 2 (SSTR2) according to immunohistochemical analysis (IHC) predict high efficacy of somatostatin ana...

Introduction: Recent studies have shown that microRNA could serve as biomarkers in various types of cancer and other diseases. Aim: To reveal microRNA that differ in patients with Cushing’s diseases (CD) and Ectopic ACTH-syndrome (EAS) to form a specific panel for differential diagnosis of ACTH-dependent Cushing’s syndrome (CS).Materials and Methods: Plasma samples from both sinuses and cubital vein were drained during in...

Purpose: Inferior petrosal sinus sampling (IPSS) is considered the gold standard test for the differential diagnosis of ACTH-dependent Cushing’s syndrome, but false-negative results have been reported in 1–10% cases. Cavernous sinus sampling (CSS) was suggested as a diagnostic tool in a complex ACTH-dependent Cushing’s syndrome cases.Aim: To study the role of bilateral combined cavernous and inferior petrosal sinus samplin...

The nicotinamide adenine dinucleotide (NAD+) dependent Poly-(ADP-ribosyl)polymerase 1 (PARP1) generates the post-translational modification ADP-Ribosylation (ADPR). Molecular studies have identified potential for NAD+ consuming enzymes to influence metabolic function. Given that PARP1 determines cellular NAD+ concentrations and ADPR shifts target protein activity, we sought to identify the molecular actions of PARP1 within skeletal muscle. Analysis of C2C12 lysates demonstrate...

• A 54-year old Lithuanian man presented with symptomatic hyperglycaemia and weight loss.• A diagnosis of new onset diabetes type 2 was confirmed for which he received treatment. In addition, his serum potassium remained low despite of intervention.• CXR was done and showed a bulky right sided hilar mass.• The combination of refractory hypokalaemia, hyperglycaemia, and lung cancer suspicio...

Background: Hypertension (HT) is common in adults with Turner Syndrome (TS) but less is known about HT in children with TS.Aim: To determine the frequency of HT in girls with TS in West of Scotland and to assess its association with clinical characteristics. Patients and methods Retrospective cross-sectional analysis of 126 girls with TS in the West of Scotland, with at least 2 clinic blood pressure (BP) measurements in the preceding 12 months. HT was de...